Signal peptide and propeptide optimization for heterologous protein secretion in Lactococcus lactis

Article Abstract:

Research has been conducted on the lactic acid bacteria producing heterologous proteins of therapeutical interest. The use of the staphylococcal nuclease in developing the heterologous protein secretion model in Lactococcus lactis is described.

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Influence of Lipoteichoic acid D-alanylation on protein secretion in Lactococcus lactis as revealed by random mutagenesis

Article Abstract:

Lactococcus lactis, is a food-grade nonpathogenic lactic acid bacterium, widely used in the food industry and is considered a good candidate for the production of heterologous proteins of therapeutic interest. An insertional mutagenesis analysis is presented, in which accessory genes involved in the production and secretion of heterologous proteins in L. lactis are identified.

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Constitutive delivery of bovine [beta]-lactoglobulin to the digestive tracts of gnotobiotic mice by engineered Lactobacillus casei

Article Abstract:

A recombinant Lactobacillus casei strain is constructed that can constitutively deliver bovine [beta]-lactoglobulin (BLG), a major cow's milk allergen, to the guts of gnotobiotic mice. The analysis of this strain has indicated that gut colonization with allergen-producing lactobacilli can help in studying the modulation of allergic disorders.

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